Movie Spoilers

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At Play in the Fields of the Lord (1991)

Andy (Darryl Hannah) gets a cold and gives it to Lewis Moon (Tom Berenger) when she lets him kiss her, and Moon ends up infecting the entire tribe, most of whom die horrible, painful deaths because they lack immunity to outside disease. Billy dies of some jungle fever, and Hazel (Kathy Bates) loses her mind, so Martin (Aidan Quinn) sends her home. At the end, the native kid who worked for Leslie (John Lithgow) kills Martin.